MedE Distinquished Seminar Series, Xiaodong Chen
Conventional electrochemical sensing techniques detect predefined molecular biomarkers for disease diagnosis, while comprised by the biases in the calibration process due to the complexity and volatility of peripheral biofluids. Meanwhile, abundant electrochemical information at the electrode-biofluid interfaces remains to be discovered to gain comprehensive metabolic signatures for diagnostic applications. Here, I would like to present an electrochemomics (EC-omics) approach to comprehensively profile the dynamics of electrochemical properties of biomolecules in peripheral biofluids during disease onset. The obtained saliva EC-omics database is compatible with various intelligent algorithms, which could accurately discriminate periodontitis (93%), surpassing the untargeted nuclear magnetic resonance data (89%), and significantly outperforming the periodontitis-related molecular biomarkers (70%) and peak intensity features (57%). Additionally, our study demonstrated the feasibility of EC-omics in human urine and mouse serum analysis, suggesting its potential to expand our understanding of the complex metabolic networks of biofluids and further foster a broader range of novel diagnostic tools across various sensing paradigms for decentralized healthcare. https://personal.ntu.edu.sg/chenxd/index.html
Biography: Professor Xiaodong Chen is a Distinguished University Professor at Nanyang Technological University (NTU), Singapore, where he is a Professor in Materials Science and Engineering, with joint and courtesy appointments in Electrical and Electronic Engineering, Chemistry, and Medicine. His research interests encompass mechanomaterials science and engineering, flexible electronics technology, surface and interface science, and carbon-negative technologies.
Prof. Chen is an elected Fellow of the Royal Society (UK), the German National Academy of Sciences Leopoldina, the Singapore National Academy of Science, and the Academy of Engineering Singapore. He serves on the editorial advisory boards of numerous esteemed international journals, including Advanced Materials, CCS Chemistry, Matter, Chemical Reviews, Small, and Nanoscale Horizons. He is currently the Editor-in-Chief of ACS Nano, a globally recognized leading journal in nanoscience and nanotechnology.